| 摘要 |
<p>A method for preparingα-keto acids, especiallyα-ketomethionine, and/or derivatives thereof, whereby an aldehyde is reacted with thiols to give a corresponding dithioacetal, the dithioacetal formed, is reacted with an electrophile in the presence of a strong base, and the resultingα,α-(dithio)carboxylic acid is solvolyzed with acid-catalysis to release thiol and give theα-keto acid or a derivative thereof. Umpolung of aliphatic or aromatic aldehydes is effected by reaction with thiols.</p> |
