发明名称 |
METHODS FOR MOBILIZING HEMATOPOIETIC STEM CELLS |
摘要 |
Disclosed are methods of mobilizing hematopoietic cells in a subject by administering to the subject a combination of Flt3 ligand (FLT3L) and a cell adhesion inhibitor. Also disclosed are methods of mobilizing hematopoietic cells in a cell culture population by contacting the cell culture population with Flt3 ligand. Mobilized hematopoietic cells can subsequently be harvested and used for hematopoietic cell transplantation. Further disclosed are compositions comprising a FLT3L, compositions comprising FLT3L and a cell adhesion inhibitor, and composition comprising FLT3L and Plerixafor. |
申请公布号 |
EP2946008(A1) |
申请公布日期 |
2015.11.25 |
申请号 |
EP20140740765 |
申请日期 |
2014.01.15 |
申请人 |
OHIO STATE INNOVATION FOUNDATION |
发明人 |
YU, JIANHUA;DEVINE, STEVEN;CALIGIURI, MICHAEL, A.;HE, SHUN |
分类号 |
A61K38/39;A61K38/19;A61P35/00 |
主分类号 |
A61K38/39 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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