| 发明名称 |
ETHYNYL DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR MODULATORS |
| 摘要 |
<p>The present invention relates to ethynyl derivatives of formula I wherein U, V, W, Y, R, R1, R2, R3 and R3' are as described herein. It has been found that the compounds of general formula I are allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5).</p> |
| 申请公布号 |
EP2763969(B1) |
申请公布日期 |
2015.11.25 |
| 申请号 |
EP20120772100 |
申请日期 |
2012.10.04 |
| 申请人 |
F.HOFFMANN-LA ROCHE AG |
发明人 |
JAESCHKE, GEORG;LINDEMANN, LOTHAR;RICCI, ANTONIO;RUEHER, DANIEL;STADLER, HEINZ;VIEIRA, ERIC |
| 分类号 |
C07D237/22;A61K31/44;A61K31/50;A61K31/505;C07D239/42 |
主分类号 |
C07D237/22 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
