Immunogenic compositions containing <i>Escherichia coli </i>H7 flagella and methods of use thereof

摘要

Immunogenic compositions containing Escherichia coli O157:H7 flagella including fusion proteins and methods using the immunogenic compositions are disclosed. Inducing an immune response in an animal to Escherichia coli O157:H7 flagella will result in prevention of colonization by Escherichia coli O157:H7 in the animal or a reduction in the amount of Escherichia coli O157:H7 infecting the animal. The immune composition will prevent or reduce the attachment of Escherichia coli O157:H7 to cells within the animal.

主权项

1. A method of generating a mucosal and/or IgA response to a target protein in a subject in need thereof, comprising parenteral administration of an adjuvant and a fusion protein comprising Escherichia coli H7 or a Toll-like receptor 5 (TLR5) activating fragment thereof and the target protein, wherein the fusion protein activates TLR5.