Bioavailable curcuminoid formulations for treating Alzheimer's disease and other age-related disorders

摘要

Curcuminoid formulations having enhanced bioavailability are provided and comprise a curcuminoid, antioxidant, glucuronidation inhibitor, and water-soluble, pharmaceutically acceptable inhibitor. A method of treating Alzheimer's and other age-related diseases by administering such a composition is also provided.

主权项

1. A curcuminoid composition having enhanced oral bioavailability, comprising:
a curcuminoid selected from the group consisting of curcumin, metabolites of curcumin, tetrahydrocurcumin, demethoxycurcumin, bisdemethoxycurcumin, curcumin esters, and mixtures thereof; an antioxidant in an amount sufficient to protect the curcuminoid from hydrolysis; a water-solubilizing, pharmaceutically acceptable carrier comprising phosphatidylcholine (PC), the water-solubilizing, pharmaceutically acceptable carrier being selected from the group consisting of lipid micelles, microemulsions and microencapsulated oils, the PC and the curcuminoid being present in the composition in a molar ratio of 1:3.33 to 6:1; and optionally a glucuronidation inhibitor, wherein the composition is suitable for oral administration, and wherein the curcuminoid and the antioxidant are present in a weight ratio of about 10:1 or greater, and the curcuminoid composition is stable above pH 7.0.