发明名称 |
Intranasal naloxone compositions and methods of making and using same |
摘要 |
Disclosed herein are compositions containing an opioid antagonist such as naloxone and one or more pharmaceutically acceptable excipients. The compositions may be used for intranasal delivery of Naloxone for the treatment of, for example, opioid overdose in an individual in need thereof. Also disclosed are methods of making compositions containing Naloxone, and devices for nasal delivery of naloxone compositions. |
申请公布号 |
US9192570(B2) |
申请公布日期 |
2015.11.24 |
申请号 |
US201414576357 |
申请日期 |
2014.12.19 |
申请人 |
AntiOp, Inc. |
发明人 |
Wyse Joseph;DeHart Michael Paul |
分类号 |
A61K31/70;A61K9/00;A61K31/485;A61K47/10;A61K47/12;A61K47/18 |
主分类号 |
A61K31/70 |
代理机构 |
Frost Brown Todd LLC |
代理人 |
Frost Brown Todd LLC |
主权项 |
1. A nasal spray composition comprising
a. from about 5 mg/mL to about 50 mg/mL of naloxone; b. from about 5 mM to about 50 mM citric acid; c. from about 2 to about 20 mM disodium ethylene diamine tetraacetic acid (EDTA); d. from about 0.1 to about 2 weight % benzyl alcohol; and e. a carrier. |
地址 |
Lexington KY US |