Tetrahydroisoquinolin-2-yl-(quinazolin-4-yl)methanone compounds

摘要

Tetrahydroisoquinolin-2-yl-(quinazolin-4-yl)methanone derivatives represented by formula (I), pharmacologically acceptable salts thereof, and compositions containing such compounds are described. Methods for treating hyperproliferative disorders by administering the compounds are also described. 1,2,3,4-tetrahydroisoquinoline derivatives for making tetrahydroisoquinolin-2-yl-(quinazolin-4-yl)methanone compounds are also described.;

主权项

1. A compound of formula (I): wherein: each R1, independently, is hydrogen, halogen, or —O—R4; R2 is —(CRaRb)z—R5; each R3, independently, is hydrogen, halogen, —N(R4)2, —O—R4, alkyl, alkoxy, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl; each Ra, independently, is hydrogen, halogen, hydroxy, alkyl, alkoxy, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl; each Rb, independently, is hydrogen, halogen, hydroxy, alkyl, alkoxy, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl; each R4, independently, is hydrogen or C1-C6 alkyl; R5 is hydrogen, halo, alkyl, hydroxy, alkyl, alkoxy, alkenyl, alkynyl, cycloalkyl, heterocyclyl, —N(R4)CO—R4 or Ar; Ar is aryl or heteroaryl, wherein each of aryl and heteroaryl is optionally substituted by one to five substituents independently selected from hydrogen, halogen, —R4, —N(R4)2, nitro, —(CH2)n—NHCO—R4, —O—R4, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl; n is 0, 1, 2, or 3; x is 0, 1, 2, 3, or 4; y is 0, 1, 2, 3, or 4; and z is 0, 1, 2, 3, 4, 5, or 6; or a pharmaceutically acceptable salt thereof.