Electrolyte and pH monitoring for fluid removal processes

摘要

Methods include monitoring indicators of blood pH or blood electrolyte levels during a blood fluid removal session and adjusting concentrations of pH buffers or electrolytes in dialysate or replacement fluid used during the session based on the monitored indicators. Blood fluid removal systems may employ sensors that monitor blood pH or electrolyte levels to adjust the fluid parameters during a blood fluid removal session.

主权项

1. A system comprising:
a blood fluid removal device comprising: (i) an inlet for receiving blood from a patient, (ii) an outlet for returning blood from the patient, (iii) a medium for removing fluid and contaminants from the blood, the medium being positioned between the inlet and the outlet, and (iv) a fluid source for carrying dialysate to the medium; a concentrate source for housing a concentrate solution comprising concentrated electrolyte or pH buffer; a concentrate flow control element for controlling the rate that the concentrate solution enters the fluid source; a first sensor configured to monitor an indicator of blood electrolyte concentration or blood pH in the blood before the blood enters the medium, a second sensor configured to monitor an indicator of blood electrolyte concentration or blood pH in the blood after the blood exits the medium and before a replacement fluid is added to the blood; and control electronics in operable communication with the first sensor and the concentrate flow control element, wherein the control electronics are configured, via the concentrate flow control element, to adjust the rate at which the concentrate solution enters the fluid source based on the rate of change of blood pH or blood electrolyte concentration based on data obtained from the first sensor and the second sensor.