发明名称 |
Process for preparation of dronedarone by mesylation |
摘要 |
The invention relates to a novel process for preparation of N-[2-n-butyl-3-[4-[3-(di-n-butylamino)-propoxy]-benzoyl]-benzofuran-5-yl]methanesulfonamide (I) and pharmaceutical acceptable salts thereof, where a salt of (5-amino-2-butyl-1-benzofuran-3-yl){4-[3-(di-n-butylamino)propoxy]phenyl}methanone of formula (II)—where A is a mono- or dibasic acid forming an acid addition salt with the compound of formula (II), n is 1 if A is dibasic acid and n is 1 or 2 if A is a monobasic acid—is reacted with a mesylating reagent in a heterogen reaction, if desired, in the presence of a phase transfer catalyst. The invention also relates to the novel salts of compound of formula (II), for the preparation thereof and their use in the preparation of dronedarone.; |
申请公布号 |
US9193703(B2) |
申请公布日期 |
2015.11.24 |
申请号 |
US201214007431 |
申请日期 |
2012.03.27 |
申请人 |
SANOFI |
发明人 |
Friesz Antal;Huszar Csaba |
分类号 |
C07D307/81 |
主分类号 |
C07D307/81 |
代理机构 |
Morrison & Foerster LLP |
代理人 |
Morrison & Foerster LLP |
主权项 |
1. A process for preparing N-[2-n-butyl-3-[4-[3-(di-n-butylamino)-propoxy]-benzoyl]-benzofuran-5-yl]methanesulfonamide (I)and pharmaceutically acceptable salts thereof, comprising reacting a salt of (5-amino-2-butyl-1-benzofuran-3-yl){4-[3-(di-n-butylamino)propoxy]phenyl}methanone of formula (II) where A is a mono- or dibasic acid forming an acid addition salt with the compound of formula (II), and n is 1 if A is dibasic acid, and n is 1 or 2 if A is a monobasic acid, with a mesylating reagent in a heterogeneous reaction, optionally, in the presence of a phase transfer catalyst. |
地址 |
Paris FR |