Apoptosis inducing compounds

摘要

Provided are compounds of formula (I):;
wherein R1, R2, R3, R4 and R5 are independently selected from the group comprising, inter aliae, H, optionally substituted, branched or linear C1-C12 alkyl, halogen atom and C1-C12 haloalkyl, and wherein A represents a single bond or an optionally substituted C1-C6 alkylene radical, notably useful for the treatment of human cancers.

主权项

1. A compound of formula (I): wherein R1, R2, R4 and R5 are independently selected from the group consisting of:
H,optionally substituted, branched or linear C1-C12 alkyl,optionally substituted, branched or linear C2-C12 alkenyl,halogen atom,C1-C12 haloalkyl,(CH2)aRa wherein a is comprised from 1 to 12 and Ra is selected from the group consisting of:
ORa1, wherein Ra1 is selected from the group consisting of optionally substituted C1-C12 alkyl, optionally substituted C6-C10 aryl, optionally substituted C3-C12 cycloalkyl, optionally substituted C2-C6 heterocycloalkyl and optionally substituted C1-C10 heteroaryl, andRa2 wherein Ra2 is selected from the group consisting of optionally substituted C6-C10 aryl, optionally substituted C3-C12 cycloalkyl, optionally substituted C2-C6 heterocycloalkyl and optionally substituted C1-C10 heteroaryl,(CH2)bRb wherein b is comprised from 0 to 12 and Rb is selected from the group consisting of:
CN,OH,C(O)Rb1 and SO2Rb1, wherein Rb1 is selected from the group consisting of H, OH, optionally substituted C1-C12 alkyl, optionally substituted C6-C10 aryl, optionally substituted C3-C12 cycloalkyl, optionally substituted C2-C6 heterocycloalkyl and optionally substituted C1-C10 heteroaryl, andNHRb2 and NHC(O)Rb2 wherein Rb2 is selected from the group consisting of H, optionally substituted C1-C12 alkyl, wherein R3 is selected from the group consisting of:
H,optionally substituted, branched or linear C1-C12 alkyl,optionally substituted, branched or linear C2-C12 alkenyl,halogen atom,C1-C12 haloalkyl,(CH2)aRa wherein a is comprised from 1 to 12 and Ra is selected from the group consisting of:
ORa1, wherein Ra1 is selected from the group consisting of optionally substituted C1-C12 alkyl, optionally substituted C3-C12 cycloalkyl, and optionally substituted C2-C6 heterocycloalkyl, andRa2 wherein Ra2 is selected from the group consisting of optionally substituted C6-C10 aryl, optionally substituted C3-C12 cycloalkyl, optionally substituted C2-C6 heterocycloalkyl and optionally substituted C1-C10 heteroaryl,(CH2)bRb wherein b and Rb are as defined above, and wherein A represents a single bond or a C1-C6 alkylene radical, optionally substituted by a C1-C6 alkyl or a C6-C10 aryl group.