发明名称 |
DRUG DELIVERY SYSTEMS COMPRISING SOLID SOLUTIONS OF WEAKLY BASIC DRUGS |
摘要 |
<p>The present invention is directed to pharmaceutical compositions and dosage forms comprising TPR beads, wherein said TPR beads comprise a solid dispersion of at least one active pharmaceutical ingredient in at least one solubility-enhancing polymer, and a TPR coating comprising a water insoluble polymer and an enteric polymer, wherein the active pharmaceutical ingredient comprises a weakly basic active pharmaceutical ingredient having a solubility of not more than 100 µg/mL at pH 6.8.</p> |
申请公布号 |
CA2661683(C) |
申请公布日期 |
2015.11.24 |
申请号 |
CA20072661683 |
申请日期 |
2007.08.29 |
申请人 |
EURAND, INC |
发明人 |
VENKATESH, GOPI;BOLTRI, LUIGI;COLOMBO, ITALO;LAI, JIN-WANG;FLABIANI, FLAVIO;MAPELLI, LUIGI |
分类号 |
A61K9/14;A61K31/4422 |
主分类号 |
A61K9/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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