| 发明名称 | Optimized Fc variants and methods for their generation | ||
| 摘要 | The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants. | ||
| 申请公布号 | US9193798(B2) | 申请公布日期 | 2015.11.24 |
| 申请号 | US201414550561 | 申请日期 | 2014.11.21 |
| 申请人 | Xencor, Inc. | 发明人 | Lazar Gregory Alan;Chirino Arthur;Dang Wei;Desjarlais John;Doberstein Stephen K.;Hayes Robert J.;Karki Sher Bahadur;Vafa Omid |
| 分类号 | C07K16/00;C12P21/08;A61K39/395;C07K16/32;C07K16/28;C07K16/22;C07K16/42;C07K1/00;A61K39/00 | 主分类号 | C07K16/00 |
| 代理机构 | Morgan, Lewis & Bockius, LLP | 代理人 | Silva Robin M.;MacDougall Christina A.;Morgan, Lewis & Bockius, LLP |
| 主权项 | 1. A protein comprising an Fc variant of a human parent IgG1 Fc polypeptide, said Fc variant comprising a first amino acid substitution at position 243 and a second amino acid substitution at position 264 in the Fc region of said parent Fc polypeptide, wherein numbering is according to the EU index. | ||
| 地址 | Monrovia CA US | ||