Compositions and methods for treating parkinson's disease

摘要

This application describes compositions of receptor inhibitors, including typical antipsychotic agents, for example haloperidol, and methods of use for treating clinical signs or symptoms of Parkinson's disease. Furthermore, this application describes compositions and methods to induce supersensitivity in dopamine D2 and other receptors involved in Parkinson's disease as a means of alleviating the clinical signs or symptoms of Parkinson's disease.

主权项

1. A method of treating Parkinson's disease and/or symptoms caused by Parkinson's disease, comprising administering, to a subject in need thereof, an amount of a haloperidol that is effective to elevate amounts of the high affinity state of the D2 receptor, inducing D2 receptor supersensitivity, wherein the amount of haloperidol is daily administration of about 0.005 mg to about 0.05 mg, for 3 to 20 days.