发明名称 |
SALIVARY MRNA PROFILING, BIOMARKERS, AND RELATED METHODS AND KITS OF PARTS |
摘要 |
<p>A method to detect a biomarker in saliva wherein the biomarker is an extracellular mRNA, comprises detecting the extracellular mRNA in the cell-free saliva; transcriptome analysis of saliva comprises detecting a transcriptome pattern in the cell-free saliva; a method to detect genetic alterations in an organ or in a gene in the organ by analyzing saliva, comprises detecting a transcriptome pattern and/or the mRNA profiling of the gene in cell-free saliva; a method to diagnose an oral or systemic pathology disease or disorder in a subject, comprises: detecting profile of a biomarker associated with the pathology disease or disorder, in particular mRNA and/or protein, in cell-free saliva and/or serum; kits comprising identifier for at least one biomarker for performing at least one of the methods; and use of salivary biomarker salivary and/or serum mRNAs as biomarkers for oral and/or systemic pathology, disease or disorder.</p> |
申请公布号 |
CA2558666(C) |
申请公布日期 |
2015.11.24 |
申请号 |
CA20052558666 |
申请日期 |
2005.02.17 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
WONG, DAVID T. W.;ST. JOHN, MAIE A. R.;LI, YANG |
分类号 |
C12Q1/68;C07H21/04 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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