Method and composition for treating alzheimer-type dementia

摘要

There is described a method for increasing the maximal tolerated dose and thus the efficacy of an acetylcholinesterase inhibitor (AChEI) in a patient suffering from an Alzheimer type dementia by decreasing concomitant adverse effects by administration of said AChEI in combination with a non-anticholinergic antiemetic agent, whereby an enhanced acetylcholinesterase inhibition in the CNS of said patient is achieved and alleviation of the symptoms of Alzheimer type dementia in said patient is thereby improved to a greater extent. The use of a non-anticholinergic antiemetic agent for the preparation of a pharmaceutical composition for the treatment of Alzheimer type dementia in combination with an acetylcholinesterase inhibitor (AChEI) and pharmaceutical compositions comprising (a) a 5HT3 receptor antagonist, a dopamine antagonist, a H1-receptor antagonist, a cannabinoid agonist, aprepitant or casopitant as an antiemetic agent and (b) an acetylcholinesterase inhibitor are also described.

主权项

1. A method for increasing the therapeutic effect of an acetylcholinesterase inhibitor (AChEI) in a patient suffering from an Alzheimer type dementia, which comprises administering to said patient, a pharmaceutical unit form comprising:
(a) a non-anticholinergic antiemetic agent; and (b) said AChEI at a dose level which is from 1.1 to 4 times greater than a recommended maximal dose level approved by the U.S. FDA.