| 摘要 |
FIELD: medicine.SUBSTANCE: invention refers to medicine, particularly to cardiology, and is applicable for the left ventricular hypertrophy (LVH) correction in elderly and senile patients with arterial hypertension. When developing the method presented as the invention, the conducted research has included 80 patients with arterial hypertension and the high risk of cardiovascular complications (23 males and 57 females) aged from 60 to 85 years (average age of 72.4±6.5 years, a median of 72 years, quartiles of 69.5 and 76 years). The duration of the disease has made 19.6±6.8 years. All the patients have undergone echocardiographic examination before treatment and 6 months later with underlying combination antihypertensive therapy. The patients have been randomised into three groups: the patients from the first group have been taking a combination of ACE inhibitors with a diuretic (perindopril 5 mg and indapamide 1.25 mg); the patients from the second group have been taking a fixed combination of ACE inhibitors and a calcium antagonist (lisinopril 5 mg and amlodipine 10 mg); the third group of patients was a reference one, which has been taking another antihypertensive therapy.EFFECT: as distinguished from a prototype according to the presented method, the left ventricular hypertrophy correction is ensured by using the fixed combinations of ACE inhibitors with a diuretic and ACE inhibitors and a calcium antagonist in the elderly and senile patients.1 dwg, 2 tbl, 2 ex |
