发明名称 |
PYRROLOPYRIMIDINE COMPOUNDS AS INHIBITORS OF CDK4/6 CDK4/6 |
摘要 |
<p>The invention is directed to novel pyrrolopyrimidine compounds of formula (1) wherein R1, R2y, R4, R8-R11, A and L are defined herein and to salts, including pharmaceutically acceptable salts thereof. The compounds of the present invention are CDK4/6 inhibitors and could be useful in the treatment of diseases and disorders mediated by CDK4/6, such as cancer, including mantle cell lymphoma, liposarcoma, non small cell lung cancer, melanoma, squamous cell esophageal cancer and breast cancer. The invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting CDK4/6 activity and to the treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.</p> |
申请公布号 |
HK1176616(A1) |
申请公布日期 |
2015.11.20 |
申请号 |
HK20130103855 |
申请日期 |
2013.03.27 |
申请人 |
NOVARTIS AG |
发明人 |
BRAIN, CHRISTOPHER, THOMAS;CHO, YOUNG SHIN;GIRALDES, JOHN, WILLIAM;LAGU, BHARAT;LEVELL, JULIAN;LUZZIO, MICHAEL;PEREZ, LAWRENCE, BLAS;WANG, YAPING;YANG, FAN |
分类号 |
C07D;A61K;A61P;C07B |
主分类号 |
C07D |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|