发明名称 |
Diagnostic, prognostic, therapeutic and screening protocols |
摘要 |
The specification describes an antibody capture process comprising (i) obtaining a biological sample comprising antibodies, (ii) contacting the biological sample with recombinant pIgR or a dIgA-binding variant, wherein the pIgR or variant binds dIgA and forms a pIgR-dIgA complex. The process may further comprise (iii) directly or indirectly assessing the level of the pIgR-dIgA complex or the level of a complex between pIgR-dIgA and an antigen of interest. There is also an antibody capture process for determining gut wall integrity in a test subject, wherein the level or ratio of SIgA to dIgA is compared to a corresponding level or ratio from a control subject. The specification provides kits embodying the process and recombinant pIgR when used for, or for use, in capturing or detecting dIgA and/or IgM. |
申请公布号 |
US2015330993(A1) |
申请公布日期 |
2015.11.19 |
申请号 |
US201314441606 |
申请日期 |
2013.11.08 |
申请人 |
THE MACFARLANE BURNET INSTITUTE FOR MEDICAL RESEARCH AND PUBLIC HEALTH LTD |
发明人 |
Anderson David Andrew;Garcia Mary Louise;Barnes Nadine Carmel;Hanafiah Khayriyyah Mohd;Landay Alan Lee |
分类号 |
G01N33/68;C07K14/705;G01N33/569 |
主分类号 |
G01N33/68 |
代理机构 |
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代理人 |
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主权项 |
1. An antibody capture process comprising (i) obtaining a biological sample comprising antibodies, (ii) contacting the biological sample with recombinant pIgR or a dIgA-binding variant, wherein the pIgR or variant binds dIgA and forms a pIgR-dIgA complex. |
地址 |
Melbourne, Victoria AU |