| 发明名称 |
FUSION PROTEIN COMPRISING GRANZYME B AND USE THEREOF |
| 摘要 |
A fusion protein including granzyme B, a cell penetrating peptide, a cleavage site, and a targeting moiety, a composition for cell membrane penetration comprising the fusion protein, and an anticancer composition comprising the fusion protein. |
| 申请公布号 |
US2015329847(A1) |
申请公布日期 |
2015.11.19 |
| 申请号 |
US201514716275 |
申请日期 |
2015.05.19 |
| 申请人 |
Samsung Electronics Co., Ltd. |
发明人 |
Lee Jae Il;Kang Hye Yoon;Shin Dongkyu;Kim Jung Min;Lee Jungmin |
| 分类号 |
C12N9/64;C07K14/00;A61K38/03;C07K4/00;A61K38/16;A61K39/395;A61K38/48;C07K16/28 |
主分类号 |
C12N9/64 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A fusion protein comprising
(1) granzyme B; or a fragment of granzyme B comprising an active region of granzyme B and a dipeptidyl peptidase I (DPPI) cleavage sequence or an auto-cleavage sequence, (2) a cell penetrating peptide, (3) a targeting moiety, and (4) a peptidase or protease cleavage site between the cell penetrating peptide and the targeting moiety. |
| 地址 |
Suwon-si KR |
