| 发明名称 |
METHOD FOR PREPARING C1Q RECOMBINANT PROTEIN |
| 摘要 |
The present invention relates to a method for recombinant production of a C1q protein or a variant of the C1q protein, in which the protein is recovered from an in vitro culture of cells expressing a C1qA subunit or a variant of the C1qA subunit, a C1qB subunit or a variant of the C1qB subunit, and a C1qC subunit or a variant of the C1qC subunit, in which at least one of the subunits or subunit variants also has at the N-terminus or C-terminus a sequence of amino acids of at least six residues, at least 40% of which are glutamic acid and/or aspartic acid residues. |
| 申请公布号 |
US2015329606(A1) |
申请公布日期 |
2015.11.19 |
| 申请号 |
US201314434385 |
申请日期 |
2013.10.09 |
| 申请人 |
COMMISSARIAT A L' ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES ;INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) |
发明人 |
THIELENS Nicole;BALLY Isabelle |
| 分类号 |
C07K14/47 |
主分类号 |
C07K14/47 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for producing a C1q protein, or a C1q protein variant, recombinantly, in which the protein is recovered from an in vitro culture of cells expressing a C1qA subunit or a C1qA subunit variant, a C1qB subunit or a C1qB subunit variant, and a C1qC subunit or a C1qC subunit variant, and in which at least one of the subunits, or at least one of the subunit variants, also bears, at the N-terminal or C-terminal end, an additional amino acid sequence of at least 6 residues, at least 40% of which are glutamic acid and/or aspartic acid residues. |
| 地址 |
Paris FR |
