PHYSICALLY DISPERSED, MOLECULARLY DISSOLVED AND/OR CHEMICALLY BOUND DRUG(S) IN AN EMPTY, HARD CAPSULE SHELL COMPOSITION

摘要

The present invention proposes a design to incorporate drug(s) in the hard capsule shells (body and cap) composition. Drug(s) in the cap and body of the capsule shell may be the same or may be different. Other drug(s) in the form of granules, beads etc. can be filled into the capsules as a core material. The drug(s) in the capsule core material may be the same as in the shell-composition or may be different. Thus, the same capsule may contain different drug(s) as the core material and in the shell. The key advantages of incorporation of drug in the capsule shell compositions are to minimize drug-drug interaction and to obtain a desired rate of release of the drug(s), mainly for potent ones. The concept can be applied to the hard gelatin, and hard non-gelatin capsules.

主权项

1. A hard shell capsule comprising: a body and a cap cooperatively defining a hollow hard shell capsule; at least one of the body and the cap composition comprising a drug(s) loaded throughout said at least one of the body and cap composition.