NASAL VACCINE AGAINST THE DEVELOPMENT OF ATHEROSCLEROSIS DISEASE AND FATTY LIVER

摘要

The present invention provides a novel vaccine compound of micellar nanoparticles to be administered intranasally to treat and/or prevent the disease called atherosclerosis, which results from an abnormal metabolism of circulating lipids. The novelty of the vaccine compound of the present invention is the use of Archaebacterian lipids, lysophosphatidylcholine, and phosphatidylcholine, which give nanoparticles stability and facilitates antigen presentation in its appropriate secondary peptidic conformation. A novel process for the preparation of vaccine compounds which allows obtaining homogeneous nanoparticles with high stability is also presented in this invention.

主权项

1. A compound vaccine of micellar nanoparticles for intranasal administration consisting of CETP carboxyl-terminus peptide as immunogen, lipids from archaebacteria, lysophospholipid, and phosphatidylcholine in a pharmaceutically acceptable vehicle.