| 摘要 |
PROBLEM TO BE SOLVED: To provide a method and a product for in vivo determination of the apoptotic state of cells in an organism.SOLUTION: This invention provides a method and a product, such as kits, useful for determining the apoptotic state of cells in an organism, including detecting the presence or abundance of at least one caspase affinity labeling agent in the cells of an animal into which at least one caspase affinity labeling agent has been introduced, in which the presence or abundance of the caspase affinity labeling agent correlates with the apoptotic state of the cells. Another embodiment of this invention provides an in vivo diagnostic method for determining the presence or absence of a disease characterized by the presence of apoptosis. The diseases include, but are not limited to, glaucoma, retinal macular degeneration, proliferative retinopathy, neuropathy, Alzheimer's disease, multiple sclerosis, Huntington's disease and cardiac diseases. |
