发明名称 |
METHODS AND COMPOSITIONS RELATING TO TREATMENT OF CANCER |
摘要 |
Compositions and methods for treating cancer in a subject in need thereof are provided according to aspects of the present disclosure which include both cetuximab and ISC-4, as a combination formulation or as separate formulations. Methods of treating cancer in a subject in need thereof are provided according to aspects of the present disclosure wherein the subject has cancer characterized by wild-type KRAS wherein the methods include administering a combination of cetuximab and ISC-4 as a combination formulation or separately, and wherein administration of the combination of cetuximab and ISC-4 provides a synergistic anti-cancer effect, treating the cancer. |
申请公布号 |
US2015328310(A1) |
申请公布日期 |
2015.11.19 |
申请号 |
US201314652363 |
申请日期 |
2013.12.20 |
申请人 |
ALLEN Joshua E.;EL-DEIRY Wifik S.;SHARMA Arun K.;IRBY Rosalyn;THE PENN STATE RESEARCH FOUNDATION |
发明人 |
Allen Joshua E.;El-Deiry Wafik S.;Sharma Arun K.;Amin Shantu G. |
分类号 |
A61K39/395;A61K31/7028;A61K31/095 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
1. A pharmaceutical composition comprising: cetuximab and ISC-4; or cetuximab and an ISC-4 prodrug. |
地址 |
Philadelphia PA US |