TETRABENAZINE MODIFIED RELEASE FORMULATION

摘要

The present invention relates to new improved tetrabenazine modified release (MR) formulations prepared by use of an advanced amorphous solid dispersion strategy. Said formulations provide a prolonged absorption phase of tetrabenazine providing reduced Cmax and increased absorption in the intestinal environment compared to known MR formulations. At the same time said formulations provide an AUC corresponding to an immediate release (IR) formulation.