| 发明名称 |
Methods and Compositions for Dengue Virus Epitopes |
| 摘要 |
The present invention provides compositions and methods of use comprising a chimeric dengue virus E glycoprotein comprising a dengue virus E glycoprotein backbone, which comprises amino acid substitutions that introduce a dengue virus E glycoprotein domain I and domain II hinge region from a dengue virus serotype that is different from the dengue virus serotype of the dengue virus E glycoprotein backbone. |
| 申请公布号 |
US2015328303(A1) |
申请公布日期 |
2015.11.19 |
| 申请号 |
US201314390312 |
申请日期 |
2013.03.15 |
| 申请人 |
The University of North Carolina at Chapel Hill ;Vanderbilt University |
发明人 |
De Silva Aravinda M.;De Alwis A. Ruklanthi;Wahala Wahala M.P.B.;Baric Ralph H.;Messer William B.;Crowe James E.;Smith Scott A. |
| 分类号 |
A61K39/12;G01N33/569;C12N7/00;C07K14/005 |
主分类号 |
A61K39/12 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An isolated dengue virus epitope that spans adjacent dengue virus E protein dimers and comprises the hinge region between domains I and II of a first E protein from a first F protein dimer and domain III of a second dengue virus E protein from a second E protein dimer. |
| 地址 |
Chapel Hill NC US |
