Non-antagonistic EGFR-binding molecules and immunoconjugates thereof

摘要

The disclosure provides anti-cancer agents, including, but not limited to, antibodies and immunoconjugates, that bind to EGFR. Specifically, the disclosure provides anti-EGFR antibodies and fragments thereof which do not inhibit EGFR signaling but are highly cytotoxic to EGFR overexpressing tumor cells. The methods of using the agents, antibodies, or immunoconjugates, for inhibiting tumor growth are also provided.