| 发明名称 |
CELL PERMEABLE INHIBITORS OF ANAPHASE PROMOTING COMPLEX |
| 摘要 |
The disclosure provides compositions and methods for treating cell cycle disorders. Compositions of the disclosure include proTAME, a prodrug analog of TAME and apcin, the combination of which inhibits an activity or function of the anaphase promoting complex (APC) by a synergistic mechanism. |
| 申请公布号 |
US2015328214(A1) |
申请公布日期 |
2015.11.19 |
| 申请号 |
US201414276994 |
申请日期 |
2014.05.13 |
| 申请人 |
President and Fellows of Harvard College |
发明人 |
KING RANDALL |
| 分类号 |
A61K31/506;A61K45/06;A61N5/10;A61K31/27 |
主分类号 |
A61K31/506 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A composition comprising a prodrug of tosyl-L-arginine methylester (TAME) and an apcin molecule or an analog or derivative thereof, wherein said composition diffuses across the plasma membrane of a cell. |
| 地址 |
Cambridge MA US |
