COMPOSITIONS AND METHODS RELATING TO COMPLEX NUCLEIC ACID NANOSTRUCTURES

摘要

The invention provides SST motifs of controlled size and shape, comprised of a plurality of oligonucleotides, and methods for their synthesis. The motifs are formed, at least in part, by the self-assembly of single stranded oligonucleotides into curved, corrugated or twisted structures. The location of each oligonucleotide in the resultant motif is known. Accordingly, the motifs may be modified with specificity.

主权项

1. A nucleic acid structure comprising
a plurality of annealed oligonucleotides, each oligonucleotide comprising at least two domains, arranged into at least two parallel double helices, wherein at least one double helix comprises a unique domain, and wherein the nucleic acid structure is curved, corrugated or twisted.