| 主权项 |
1. A process comprising:
(A) reacting, in a reaction zone that comprises a solvent, an amine, and a carbonyl to produce an enamine and H2O
(1) wherein said amine has the following formula wherein R4 and R5 are each independently selected from C1-C8 alkyl, C3-C8 cycloalkyl, C2-C8 alkoxyalkyl, C7-C12 arylalkyl, C2-C8 alkylaminoalkyl, aryl, and heteroaryl, or R4 and R5 taken together with N represent a 5- or 6-membered saturated or unsaturated ring; and(2) wherein said carbonyl is an aldehyde or a ketone and has the following formula (a) wherein R1 and R2 is each independently selected from C1-C8 alkyl, C3-C8 cycloalkyl, C2-C8 alkoxyalkyl, C7-C12 arylalkyl, C2-C8 alkylaminoalkyl, aryl, and heteroaryl, each of which is independently substituted with one or more S—R6 wherein each R6 is independently selected from C1-C8 alkyl, C3-C8 cycloalkyl, C2-C8 alkoxyalkyl, C7-C12 arylalkyl, C2-C8 alkylaminoalkyl, aryl, and heteroaryl, and(b) wherein R3 is selected from H, C1-C8 alkyl, C3-C8 cycloalkyl, C2-C8 alkoxyalkyl, C7-C12 arylalkyl, C2-C8 alkylaminoalkyl, aryl, and heteroaryl;(3) wherein said reacting, in said reaction zone, is conducted under distillation conditions comprising
(a) a pressure from about 100 Pa to about 120,000 Pa, and(b) a temperature below about, but preferably below, the thermal decomposition temperature of said enamine during said reacting; and(4) wherein said solvent initially comprises a non-polar-high-boiling-point liquid, a polar-high-boiling-point-liquid, and then further comprises H2O produced from the condensation of said amine and said carbonyl to produce said enamine; and (B) removing a vapor phase from said reaction zone wherein said vapor phase comprises H2O. |
