METHODS FOR PROVIDING RAPID RELIEF OF MOTOR FLUCTUATIONS IN A PARKINSON'S DISEASE PATIENT

摘要

The present invention provides methods of providing rapid relief of motor fluctuations in a Parkinson's disease patient. The methods of the invention comprise pulmonary administration of levodopa by inhalation at therapeutically effective concentrations such that the patient's plasma levodopa concentration increases by at least about 200 ng/ml within 10 minutes or less post inhalation as compared to the concentration of levodopa in the patient's plasma prior to inhalation of the levodopa and wherein the patient's plasma concentration remains increased by at least about 200 ng/ml for a time period of at least 15 minutes after inhalation. The methods of the invention are particularly useful for treatment of motor fluctuations which arise as a result of poorly controlled levodopa plasma levels in a patient.

主权项

1. A method of providing rapid relief of motor fluctuations in a Parkinson's disease patient comprising:
administering at least one dose of levodopa by inhalation to a Parkinson's disease patient; wherein within about 10 minutes of administration of levodopa by inhalation, the patient's plasma levodopa concentration increases by at least about 200 ng/ml as compared to the patient's plasma levodopa concentration prior to administration; and wherein said patient's plasma levodopa concentration maintains said increase of at least about 200 ng/ml for a time period of at least about 15 minutes after administration.