| 主权项 |
1) An oral dosage form for the immediate release of at least one active compound, comprising coated particles, each of said particles consisting of a non-monocrystalline core containing at least said active compound, said core being coated with at least one coating layer comprising:
(A) at least 15% by weight of a polymer selected from the group consisting of ethylcellulose, cellulose acetate, cellulose acetate butyrate, ammonio (meth)acrylate copolymers, polymers and copolymers of (meth)acrylic acid esters, polyvinyl acetate and mixtures thereof; and (B) at least 40% by weight of a polymer chosen from low molecular weight polyvinylpyrrolidone, low molecular weight hydroxypropyl methylcellulose, low molecular weight hydroxypropyl cellulose, low molecular weight methylcellulose, low molecular weight hydroxyethyl cellulose, hydroxyethyl methylcellulose, maltodextrin, poloxamers, polyethylene glycols having a molecular weight strictly comprised between 3,000 and 20,000 g/mol, polyvinyl alcohols, vinyl pyrrolidone-vinyl acetate copolymers, xanthan gum, acacia gum, carrageenan gum, guar gum, carob gum, agar-agar, copolymers of methylvinyl ether and maleic anhydride or maleic acid, aminoalkyl methacrylate copolymers, copolymers of butyl methacrylate, 2-dimethylaminoethyl methacrylate and methyl methacrylate 1/2/1, polyvinyl acetate diethyl aminoacetates, the polyvinyl aminoacetals, and mixtures thereof; the weight ratio polymer (B)/polymer (A) being comprised between 85/15 and 50/50; and said coating layer representing at least 30% by weight of the total weight of said coated particles. |
