Anti-IL-23 Antibodies, Compositions, Methods and Uses

摘要

An anti-IL-23 antibody, including isolated nucleic acids that encode at least one anti-IL-23 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.

主权项

1. An isolated IL-23p19 antibody, comprising a light chain variable region and a heavy chain variable region, said light chain variable region comprising:
a complementarity determining region light chain 1 (CDRL1) amino acid sequence of SEQ ID NO:39; a CDRL2 amino acid sequence of SEQ ID NO:40; and a CDRL3 amino acid sequence of SEQ ID NO:41,and said heavy chain variable region comprising:
a complementarity determining region heavy chain 1 (CDRH1) amino acid sequence of SEQ ID NO:34; a CDRH2 amino acid sequence of SEQ ID NO:35; and a CDRH3 amino acid sequence of SEQ ID NO:36.