WT1 Vaccine

摘要

Disclosed herein are nucleic acid molecules comprising one or more nucleic acid sequences that encode a mutated WT1 antigen. Vectors, compositions and vaccines comprising one or more nucleic acid sequences that encode a mutated WT1 antigen are disclosed. Methods of treating an individual who has a WT1-expressing tumor and methods of preventing a WT1-expressing tumor are disclosed. Mutated WT1 antigen is disclosed.

主权项

1. An isolated nucleic acid molecule comprising one or more nucleic acid sequences selected from the group consisting of: a nucleic acid sequence that encodes SEQ ID NO:2, a nucleic acid sequence that encodes a fragment comprising at least 90% of a length of SEQ ID NO:2, a nucleic acid sequence that encodes a protein that is at least 98% identical to SEQ ID NO:2, a nucleic acid sequence that encodes a fragment comprising at least 90% of a length of a protein that is at least 98% identical to SEQ ID NO:2, a nucleic acid sequence that encodes SEQ ID NO:4, a nucleic acid sequence that encodes a fragment comprising at least 90% of a length of SEQ ID NO:4, a nucleic acid sequence that encodes a protein that is at least 98% identical to SEQ ID NO:4, and a nucleic acid sequence that encodes a fragment comprising at least 90% of a length of a protein that is at least 98% identical to SEQ ID NO:4.