PHARMACEUTICAL COMPOSITIONS AND METHODS FOR FABRICATION OF SOLID MASSES COMPRISING POLYPEPTIDES AND/OR PROTEINS
摘要
Embodiments of the invention provide shaped masses comprising one or more drugs such as proteins or polypeptides and methods for forming such shaped masses. One embodiment provides a shaped mass comprising a drug such as a protein or polypeptide having a biological activity in the body of a mammal. The shaped mass is formed by compression of a precursor material comprising the drug wherein an amount of biologically active drug in the mass is a preserved above a minimum level. Drugs which may be incorporated into the shaped mass may include one or more glucose regulating proteins such as insulin, incretins; and immunoglobulins such as TNF-inhibiting antibodies or interleukin neutralizing antibodies. Embodiments of the shaped mass may be incorporated into a tissue penetrating member which is inserted into the intestinal wall allowing for the oral delivery of proteins and peptides which would otherwise be degraded in the intestinal tract.
申请公布号
CA2949236(A1)
申请公布日期
2015.11.19
申请号
CA20152949236
申请日期
2015.05.15
申请人
INCUBE LABS, LLC;MORALES, MERCEDES;IMRAN, MIR;KORUPOLU, RADHIKA;HASHIM, MIR
发明人
MORALES, MERCEDES;IMRAN, MIR;KORUPOLU, RADHIKA;HASHIM, MIR