METHOD FOR PRODUCING METHYL{4,6-DIAMINO-2-[1-(2-FLUOROBENZYL)-1H-PYRAZOLO[3,4-B]PYRIDINE-3-YL]PYRIMIDINE-5-YL} METHYLCARBAMATE AND ITS PURIFICATION FOR USE THEREOF AS PHARMACEUTICALLY ACTIVE SUBSTANCE

摘要

PROBLEM TO BE SOLVED: To provide a method for producing methyl{4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-yl]pyrimidine-5-yl} methylcarbamate (I).SOLUTION: This invention provides a method for synthesizing a compound of formula (I) by a pyridine-free reaction between formula (VIII) and methyl chloroformate or dimethyl dicarbonate and further a reaction with a methylation agent.