COMPOSITIONS AND METHODS FOR REGULATING ERYTHROPOIESIS

摘要

The present application discloses a previously unknown function of CD24 expressed on a subset of dendritic cells. The invention encompasses regulating CD24 on these cells to regulate erythropoiesis, induce EPO production and levels, increase RBC levels, and to treat, for example, stress-mediated erythropoiesis. The compositions and methods of the invention are useful, for example, in treating anemia.

主权项

1. A method of stimulating erythropoiesis in a subject, said method comprising administering to said subject a pharmaceutical composition comprising a pharmaceutically-acceptable carrier, an effective amount of at least one agonist of CD24, and optionally at least one additional therapeutic agent, thereby stimulating erythropoiesis in a subject.