| 发明名称 |
DETECTION OF HISTONE MODIFICATION IN CELL-FREE NUCLEOSOMES |
| 摘要 |
This invention relates to the diagnosis of disease conditions, such as cancer and autoimmune disease, by the analysis of cell-free nucleosomes in samples from individuals. Methods of the invention may include contacting cell-free nucleosomes from a biological fluid sample obtained from the individual with an antibody that binds specifically with a modified histone protein. Binding of the antibody to the nucleosomes is indicative that the individual has the disease condition. |
| 申请公布号 |
US2015330996(A1) |
申请公布日期 |
2015.11.19 |
| 申请号 |
US201514816329 |
申请日期 |
2015.08.03 |
| 申请人 |
SINGAPORE VOLITION PTE. LIMITED |
发明人 |
BAWDEN Lindsay Jane;BONE Elizabeth Ann;DRUMMOND Alan Hastings;NEEDHAM Lindsey Ann |
| 分类号 |
G01N33/68 |
主分类号 |
G01N33/68 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of assessing a disease condition in an individual comprising;
contacting nucleosomes from a biological fluid sample obtained from the individual with an antibody which binds specifically with a modified histone protein to identify a nucleosome comprising a modified histone protein, and isolating DNA associated with the nucleosome comprising a modified histone. |
| 地址 |
SINGAPORE SG |
