THIOETHER DERIVATIVES AS PROTEIN KINASE INHIBITORS

摘要

The present invention relates to thioether derivatives (1) as protein kinase inhibitors, which are useful for the treatment, relieve and/or prevention of diseases associated with abnormal and hyperproliferation of cells in a mammal, especially humans, and which are particularly useful for the treatment of all forms of cancer.;

主权项

1. A protein kinase inhibitor according to general formula (1) or a pharmaceutically acceptable salt thereof: wherein X is selected from N and CH; Y is selected from NH, S and O; Z is selected from N and CH; R1 is selected from a substituted or unsubstituted aryl group and a substituted or unsubstituted heteroaryl group; R2 is selected from a substituted or unsubstituted alkyl group, a substituted or unsubstituted aryl group and a substituted or unsubstituted heteroaryl group; n is selected from 0, 1 and 2; and Q is selected from H and a substituted or unsubstituted amino group.