发明名称 |
GENETICALLY MODIFIED NON-HUMAN ANIMALS EXPRESSING HUMAN EPO |
摘要 |
Genetically modified non-human animals expressing human EPO from the animal genome are provided. Also provided are methods for making non-human animals expressing human EPO from the non-human animal genome, and methods for using non-human animals expressing human EPO from the non-human animal genome. These animals and methods find many uses in the art, including, for example, in modeling human erythropoiesis and erythrocyte function; in modeling human pathogen infection of erythrocytes; in in vivo screens for agents that modulate erythropoiesis and/or erythrocyte function, e.g. in a healthy or a diseased state; in in vivo screens for agents that are toxic to erythrocytes or erythrocyte progenitors; in in vivo screens for agents that prevent against, mitigate, or reverse the toxic effects of toxic agents on erythrocytes or erythrocyte progenitors; in in vivo screens of erythrocytes or erythrocyte progenitors from an individual to predict the responsiveness of an individual to a disease therapy. |
申请公布号 |
US2015327524(A1) |
申请公布日期 |
2015.11.19 |
申请号 |
US201514715446 |
申请日期 |
2015.05.18 |
申请人 |
Regeneron Pharmaceuticals, Inc. ;Yale University ;Institute for Research in Biomedicine (IRB) |
发明人 |
Murphy Andrew J.;Stevens Sean;Flavell Richard;Manz Markus Gabriel;Shan Liang |
分类号 |
A01K67/027;C07K14/475;C07K14/54;C07K14/535;C12N9/14;C07K14/505 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
1. A genetically modified non-human animal, comprising:
a nucleic acid sequence that encodes a human EPO protein (hEPO) operably linked to an EPO gene promoter. |
地址 |
Tarrytown NY US |