CHIMERIC ANTIGEN RECEPTORS AND IMMUNE CELLS TARGETING B CELL MALIGNANCIES

摘要

The disclosure describes genetically engineered CD37 specific redirected immune effector cells expressing a chimeric antigen receptor (CAR) protein comprising an antigen binding domain derived from an antibody, a single chain antibody or portion thereof that binds CD37; a hinge region; a transmembrane domain and an intracellular signaling domain derived from human CD3ζ or FcRγ; and optionally one or more co-stimulatory intracellular signaling domains The invention includes nucleic acids, vectors and immune effector cells associated with the production of the CAR protein, as well as methods of treating B cell malignancies in humans by cellular immunotherapy.

主权项

1. A nucleic acid construct encoding a chimeric immune receptor, wherein said chimeric immune receptor binds an antigen on a target tumor cell, wherein upon introduction of said nucleic acid construct into an immune effector cell, said immune effector cell expresses the chimeric immune receptor and mediates direct killing of the target tumor cell through clustering of the antigen on the target tumor cell surface upon engagement of the antigen in the presence of an immune suppressive tumor microenvironment.