FUSION POLYPEPTIDES AND USES THEREOF

摘要

The present invention provides Relaxin fusion polypeptides with extended half-life. Thereby, the half-life extending parts are either the Fc moiety of the human IgG2 or of the human IgG4. Furthermore, the invention provides nucleic acid sequences encoding the foregoing fusion polypeptides, vectors containing the same, pharmaceutical compositions and medical use of such fusion polypeptides.

主权项

1. A fusion polypeptide having Relaxin activity comprising in order from the amino-terminus to the carboxy-terminus:
a. a IgG2 or IgG4 Fc domain, b. a stretcher unit, and c. the scRelaxin polypeptide having the underlined sequence as shown in FIG. 2.