Methods of Treating Hepatic Fibrosis and Associated Diseases by Regulating Rev-ERB Activity

摘要

The present invention is directed to compositions and associated methods for treatment, prevention, amelioration, and/or delaying the onset of hepatic fibrosis and/or associated diseases. The methods preferably involve regulating at least one of Rev-erbα expression, activity, and subcellular localization. In particular, certain embodiments of the present invention relate to compositions and methods of using a Rev-erb-modulating agent (REMA) for the treatment or prevention of hepatic fibrosis and/or associated diseases. Preferably, the amount of a REMA administered comprises a quantity sufficient to modulate at least one of Rev-erbα expression, activity, and subcellular localization and reduce the activation of hepatic stellate cells (HSCs).

主权项

1. A method of treating, preventing, ameliorating, and/or delaying the onset of liver fibrosis and related pathologies in a mammal in need thereof, comprising: administering a composition comprising a therapeutically effective amount of one or more Rev-erb—modulating agents (REMA) to the mammal, wherein said one or more REMA modulates at least one of Rev-erbα expression, activity, and subcellular localization in at least a portion of the mammal's hepatic stellate cells (HSCs).