| 摘要 |
PROBLEM TO BE SOLVED: To provide a nucleic acid-containing external preparation composition exhibiting good skin permeability.SOLUTION: A nucleic acid is dissolved in a lower fatty acid-based ionic liquid of a triethanolamine salt or a diethanolamine salt, and a fatty acid-based ionic liquid of an organic solvent and/or a triisopropanolamine salt or a diisopropanolamine salt is added to adjust the solubility of the nucleic acid, making a mixed ionic liquid solution of the nucleic acid. By mixing the ionic liquid solution with an ointment base or a matrix plaster base, followed by dispersion, a nonaqueous external preparation composition is made. The external preparation composition containing nucleic acid is an external preparation composition excellent in skin permeability and can provide a suitable external preparation composition according to the kind of nucleic acid. |
