| 摘要 |
<p>The whole plant Fagonia bruguieri DC., family Zygophyllaceae was extracted with boiling water and freeze-dried. The LD<SUB>50</SUB> values of the dried extract were 11.5 and 10.75 g/kg i.p. in mice and rats, respectively. Treatment of albino guinea-pigs with the extract in doses of 200 mg/kg (i.v.) or orally antagonized histamine (20 µg/kg i.v.) - and capsaicin (100 µg/kg i.v.) - induced bronchoconstriction without affecting that induced with ACh and 5-HT. The percentage antagonisms were 72 ± 0.9 and 65 ± 4% against histamine and capsaicin, respectively (P < 0.01, N = 10). Exposure of conscious guinea-pigs to histamine aqueous aerosols (10 mg/ml) induced initial graspings and reversible loss of consciousness within 5 minutes. Treatment of the guinea-pigs with the extract in doses of 1.25 g/kg (i.p.) for 20 minutes or orally for 2 hours protected significantly the animals against histamine-induced grasps and loss of consciousness (P < 0.01, N = 11). Fagonia bruguieri freeze-dried aqueous extract and its constituents are claimed to be potential new treatment for allergy.</p> |
