Immunoconjugates, compositions for making them, and methods of making and use

摘要

An immunoconjugate in which a phosphate-prodrugged DNA minor groove binding agent of formula (I), where X is a nucleophilically displaceable leaving group, is conjugated to an antibody or an antigen binding fragment of an antibody, and compounds that can be used for making such immunoconjugates, and uses of such immunoconjugates.;

主权项

1. An immunoconjugate wherein a compound of the formula (I) wherein X is a nucleophilically displaceable leaving group, or a pharmaceutically acceptable salt thereof, is conjugated at the —NH2 group thereof via a peptidyl linker to an antibody or an antigen binding fragment such antibody.