| 发明名称 | Immune stimulatory oligonucleotide analogs containing modified sugar moieties | ||
| 摘要 | The invention relates to oligonucleotides including at least one FANA substituted nucleotide analog and a pyrimidine-purine dinucleotide. The invention also relates to pharmaceutical compositions and methods of use thereof. | ||
| 申请公布号 | US9186399(B2) | 申请公布日期 | 2015.11.17 |
| 申请号 | US200812681800 | 申请日期 | 2008.09.29 |
| 申请人 | AdiutTide Pharmaceuticals GmbH | 发明人 | Uhlmann Eugen;Debelak Harald;Jurk Marion;Weber Markus |
| 分类号 | A61K39/39;A61K39/00;C12N15/117 | 主分类号 | A61K39/39 |
| 代理机构 | Smith Patent | 代理人 | Smith Chalin A.;Smith Patent |
| 主权项 | 1. An immunomodulatory oligonucleotide 8-200 nucleotides in length, comprising at least one immunomodulatory GNCG motif, wherein N is T, A, or a 5-substituted U; and wherein at least one G comprises a 2′-deoxy-2′fluoro-β-D-arabinose (FANA)-modified purine nucleoside. | ||
| 地址 | Frankfurt am Main DE | ||