| 发明名称 | Compositions and methods for the treatment of glomerulonephritis | ||
| 摘要 | The invention provides compositions and methods for the treatment of glomerulonephritis. In one embodiment, the invention provides a compound of formula (I) R-L-CO—X (I) (wherein R is a C10-24 unsaturated hydrocarbon group optionally interrupted by one or more heteroatoms or groups of heteroatoms selected from S, O, N, SO, SO2, said hydrocarbon group comprising at least 4 non-conjugated double bonds; L is a linking group forming a bridge of 1 to 5 atoms between the R group and the carbonyl CO; andX is an electron withdrawing group) or a salt thereoffor use in the treatment of glomerulonephritis. | ||
| 申请公布号 | US9187396(B2) | 申请公布日期 | 2015.11.17 |
| 申请号 | US201414200238 | 申请日期 | 2014.03.07 |
| 申请人 | Avexxin AS | 发明人 | Johansen Berit;Huwiler Andrea |
| 分类号 | A01N43/00;A61K31/33;A01N35/00;A61K31/12;C07C49/227;A61K31/121;A61K31/131;A61K31/381;C07C229/12;C07C317/44;C07C323/52;C07D333/24;C07D333/38 | 主分类号 | A01N43/00 |
| 代理机构 | Mintz Levin Cohn Ferris Glovsky and Popeo, P.C. | 代理人 | Mintz Levin Cohn Ferris Glovsky and Popeo, P.C. ;Corless Peter F.;Cowles Christopher R. |
| 主权项 | 1. A method of treating lupus nephritis or diabetic nephropathy comprising administering to an animal in need thereof an effective amount of a compound selected from the group consisting of where X is CF3. | ||
| 地址 | Trondheim NO | ||