Method and apparatus for organ specific inflammation monitoring

摘要

An apparatus comprises an implantable sensor and a detection circuit. The implantable sensor provides a physiologic sensor signal and is to be positioned at a lymph node of a subject. The detection circuit detects a change in a physiologic parameter of the lymph node that exceeds a threshold change, and deems that the change in the physiologic parameter indicates a change in inflammation of an organ associated with the lymph node.

主权项

1. An apparatus comprising:
an implantable sensor configured to be positioned at a lymph node of a subject, wherein the implantable sensor provides a physiologic sensor signal; a therapy circuit configured to provide one or more of cardiac pacing therapy, cardiac resynchronization therapy, cardioversion therapy, and cardiac defibrillation therapy; and a detection circuit configured to:
detect a change in a physiologic parameter of the lymph node that exceeds a threshold change wherein the change in the physiologic parameter includes at least one of a change in the electrical impedance of the lymph node that exceeds a threshold impedance change and a change in at least one of a change in size of the lymph node that exceeds a threshold size change;generate an indication that the change in the physiologic parameter corresponds to a change in physiological status associated with the lymph node; andadjust a parameter of the one or more of cardiac pacing therapy, cardiac resynchronization therapy, cardioversion therapy; and cardiac defibrillation therapy in response to the generated indication.