Small tissue property change detection in magnetic resonance guided intervention

摘要

Small tissue property change detection is provided for magnetic resonance (MR) guided intervention. T1 changes from before and after treatment are compared. The comparison identifies locations of possible change. The comparison is performed for different times, one before and one after a zero-crossing of a signal intensity time curve. Due to the characteristics of the T1 mapping, common locations from the different times will have reversed contrast. Clustering and this reversal are used to distinguish the treatment region from noise.

主权项

1. A method for tissue property change detection in magnetic resonance (MR) guided intervention, the method comprising:
acquiring, with an MR scanner, a MR intensity curve of tissue response over time in response to an inversion pulse; determining, with a processor, a first time before a zero crossing of the MR intensity curve and a second time after the zero crossing; identifying first locations from a comparison of an MR T1 map for the first time from before the MR guided intervention to an MR T1 map for the first time from after therapy in the MR guided intervention; identifying second locations from a comparison of an MR T1 map for the second time from before the MR guided intervention to an MR T1 map for the second time from after therapy in the MR guided intervention; locating tissue common to the first and second locations and with a reversed contrast for the first time as compared to the second time; and generating an image indicating the common tissue.